DESIGN AND DEVELOPMENT OF NOVEL MUCOADHESIVE GASTRORETENTIVE FORMULATION OF GLIPIZIDE
نویسندگان
چکیده
منابع مشابه
Formulation and evaluation of mucoadhesive glipizide films.
Glipizide is mainly absorbed in the proximal areas of the gastrointestinal tract. The purpose of this study was formulation and evaluation of mucoadhesive films to prolong the stay of drug in its absorption area. Glipizide was formulated in a mucoadhesive film that could be retained in the stomach for prolonged intervals. Polymeric films were designed with various compositions of hydroxypropyl ...
متن کاملDevelopment of Mucoadhesive Buccal Films of Glipizide
For improving bioavailability in controlled release fashion and to circumvent the hepatic first pass effect of glipizide mucoadhesive buccal films of glipizide were prepared by solvent casting technique. Buccal films were prepared using hydroxy propylmethylcellulose, sodium carboxymethylcellulose, carbopol934P and Eudragit RL-100. Films were evaluated for their weight, thickness, surface pH, sw...
متن کاملFormulation and in Vitroevaluation of Glipizide Mucoadhesive Buccal Tablets
The aim of study was to prepare and characterize mucoadhesive buccal tablets of glipizide using different Mucoadhesive polymers such as Carbopol 940, Sodium alginate and HPMC K15M in combination. Twenty one formulation were developed with different concentration of mucoadhesive polymers in each formulation.The formulated buccal tablets were tested for surface pH,in vitro drug release and moistu...
متن کاملDesign and Development of Mucoadhesive Acyclovir Tablet
The purpose of this study was to design and optimize an oral controlled release acyclovir mucoadhesive tablet, in term of its drug release and mucoadhesive strength. A 32 full factorial design was employed to study the effect of independent variables like Carbopol-934P and hydroxypropyl methylcellulose K100M, which significantly influence characteristics like swelling index, ex-vivo mucoadhesiv...
متن کاملDesign and Development of Mucoadhesive Acyclovir Tablet
The purpose of this study was to design and optimize an oral controlled release acyclovir mucoadhesive tablet, in term of its drug release and mucoadhesive strength. A 32 full factorial design was employed to study the effect of independent variables like Carbopol-934P and hydroxypropyl methylcellulose K100M, which significantly influence characteristics like swelling index, ex-vivo mucoadhesiv...
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ژورنال
عنوان ژورنال: International Journal of Research in Ayurveda & Pharmacy
سال: 2014
ISSN: 2277-4343
DOI: 10.7897/2277-4343.055128